Science Behind Kambo

Kambo contains a number of active compounds (which are all peptides):

Dermorphin — a potent mu-opioid receptor agonist.

Deltorphin — a very potent delta-opioid receptor agonist.

Phyllomedusin — a tachykinin which affects the salivary glands, tear ducts, intestines, and bowels; it contracts the smooth muscles and contributes to a violent purge.

Phyllokinin (and phyllomedusin) — potent blood vessel dilators that also increase the permeability of the blood-brain barrier.

Phyllocaerulein — which stimulates the adrenal cortex and the pituitary gland, causes a fall in blood pressure, causes tachycardia, and has a potent action on the gastrointestinal smooth muscle, and stimulates gastric, biliary and pancreatic secretions.

Sauvagine — which stimulates the adrenal cortex, causes a long-lasting fall in blood pressure and causes intense tachycardia.

Adenoregulin — acts on the adenosine receptors.

Dermaseptin — a potent antimicrobial for both Gram-positive and Gram-negative bacteria, and antiviral for herpes simplex virus.

Scientific research has identified the peptides dermorphin and deltorphin in kambo as potent opioid peptides.

Opioids are painkillers and opioid peptides bind to receptors on human cells which trigger a pain masking response.

Dermorphin is amazingly 30-40 times stronger than morphine.